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The expression level of Gpx3 significantly increased in GPX3-overexpressing tenocytes (Figure 7B), whereas that of the other antioxidant enzymes or collagen type 1 was unaltered (Supplementary Figure S4)

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3.2 Miscellaneous sources There are many exogenous sources of ROS generation, for examples, transition metal ions likely iron (Fe), zinc (Zn) and copper (Cu) have the abilities to induce oxidative stress in living cells via performing Fenton and Haber-Weiss reactions