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Huang TL, Zandi PP, Tucker KL, Fitzpatrick AL, Kuller LH, Fried LP, et al

Antioxidants 11 (2), 298

These pathways are coordinated by S-adenosylmethionine (SAM), which have a specific role as an allosteric inhibitor for the methylenetetrahydrofolate reductase (MTHFR) reaction and acts as an activator of cystathionine -synthase (CBS) [2]

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While this patient has a borderline-high platelet count, his primary abnormality is severe erythrocytosis, making a Janus kinase 2 mutation much more likely than a thrombopoietin receptor mutation