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10.1080/14786419.2013.814053 268 SunY

2014;9(3):e93388

A review of ketogenic diet and lifestyle

Acute ER stress ( Figure 4A ) activates a regulated UPR, promoting cell survival, whereas prolonged ER stress ( Figure 4B ) causes UPR hyperactivation leading to apoptosis (80)

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Concurrently, it suppresses aberrant inflammatory cascades through downregulation of key cytokines via NO signaling, while inhibiting inflammasome hyperactivity