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Yet, we demonstrate that impaired Cl - extrusion underlies the failure of L838,417 to induce analgesia at high doses due to a resulting collapse in Cl - gradient, dramatically limiting the benzodiazepine therapeutic window

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3A).In the Sham group, the structure of prostate epithelial cells was intact and well-defined, arranged in a single layer with a regular glandular lumen shape, and pink secretions were present within the lumen

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