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Accurately predicting protein pK a values using nonequilibrium alchemy

Neuroprotective Properties: Offers protective benefits for the nervous system, which may help in recovering from nerve damage

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Through in silico analyses, the authors hypothesized that this effect could be due to the high binding affinity of VitB12 with the CD14 receptor that could inhibit LPS transport and thereby, avoid TLR4 activation (Figure 4A) [82]

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