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Without adequate inflammation, healing impaired (immunosuppressed patients show delayed fracture healing)

Increased stress response and beta-phenylethylamine in MAOB-deficient mice

Dietary apigenin reduces induction of LOX-1 and NLRP3 expression, leukocyte adhesion, and acetylated low-density lipoprotein uptake in human endothelial cells exposed to trimethylamine-N-oxide

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In the U.S., this results in approximately: ~56,000 emergency room visits annually ~2,600 hospitalizations ~500 deaths from liver failure each year making acetaminophen overdose the leading cause of acute liver failure in the United States (18)

Corcoran RB, Do KT, Kim JE, Cleary JM, Parikh AR, Yeku OO, Xiong N, Weekes CD, Veneris J, Ahronian LG, Mauri G, Tian J, Norden BL, Michel AG, Van Seventer EE, Siravegna G, Camphausen K, Chi G, Fetter IJ, Brugge JS, Chen H, Takebe N, Penson RT, Juric D, Flaherty KT, Sullivan RJ, Clark JW, Heist RS, Matulonis UA, Liu JF, Shapiro GI