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Available evidence suggests a role for voltage-dependent anion channel (VDAC), located in the OMM, and adenine nucleotide translocase (ANT) across the IMM ( 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Sileikyte et al., 2014)

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Lysyl oxidase, the copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin (a step required for the cross-linking that gives mature collagen and elastin their mechanical properties), requires copper as a cofactor

doi: 10.1038/s41598-017-01732-1 80 ConnellyPJPrenticeNPCouslandGBonhamJ

However, since the vital role of this phenomenon in other neurological dysfunction such as Parkinsons disease as mentioned above, it is essential to explore the concrete role of ubiquitination by HDACs for epileptic progression