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Tretinoin is that active retinoic acid already, so it binds skin receptors directly and acts faster

however, glucose deficiency, lactate buildup, and lipid uptake can influence T cell activation and energy metabolism

Int J Mol Sci 18(10):2076

Treatment with MnTBAP reversed cardiac mitochondrial oxidative stress and improved mitochondrial bioenergetics in a mouse model of the metabolic syndrome [150]