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Evidence indicates that the GM markedly elevates circulatory 25-hydroxyvitamin VitD levels by promoting the production of lactic acid and 7-dehydrocholesterol, therefore aiding skeletal calcium absorption (200)

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Frye, F

In addition, melatonin supplements with a wide range of dosage from 1 to 24 mg in mild cognitive impairment enhanced rest-activity rhythms and improved sleep profiles such as sleep quality, morning alertness, and sleep onset latency in a comprehensive review including 11 studies [42]

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High drug loading efficiency is a critical requirement, as it offers economic efficiencyreducing drug loss during manufacturingand enhances potential drug performance, by allowing lower doses to achieve the desired effect and thereby minimizing toxicity risk (Liu et al., 2020