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The methylation cycle is deeply intertwined with immune regulation, histamine clearance, and even the structural integrity of our tissues, making L-5-MTHF highly relevant for patients dealing with hyperactive immune responses and hypermobility: Mast Cell Activation Syndrome (MCAS): Histamine is broken down in the body by an enzyme called HNMT, which relies entirely on SAMe (S-adenosylmethionine) to function

Int J Dev Neurosci 25, 367372 (2007)

Nausea, vomiting and fatigue can make drinking enough water and eating and retaining enough nutritious food challenging

Dihexa's ability to promote neural circuit repair and neuron survival has generated interest in the TBI recovery space

10.1083/jcb.200407053 J

Lyophilized peptides may remain stable at room temperature for several weeks when intended for near-term use