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Zhou F, Chen S

Monitoring & Follow-Up Regular check-ins to review progress and adjust treatment

Severe deficiencies are best corrected by injections, while mild deficiencies, can be taken care of by oral or sublingual medicines

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The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

doi: 10.3389/fcell.2025.1623959 Received 06 May 2025 Accepted 04 August 2025 Published 20 August 2025 Volume 13 - 2025 Edited by Valerie Kouskoff, The University of Manchester, United Kingdom Reviewed by Soumya Ranjan Jena, Ravenshaw University, India Vinod Reddy Lekkala, University of California, San Francisco, United States Updates Copyright 2025 Feng and He