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In contrast, conditional deletion of S1P 1 in neuronal cell lineages had no impact on EAE severity or the efficacy of FTY720 to suppress EAE

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NPD1 not only reduces infarct size and improves neurological recovery but also attenuates inflammation by inhibiting NF-B activation, downregulating COX-2 expression, and limiting polymorphonuclear neutrophil (PMN) infiltration [176]

Meng, W., Pan, W., Zhang, A.J.X., Li, Z., Wei, G., Feng, L., Dong, Z., Li, C., Hu, X., Sun, C., Luo, Q., Yuen, K-Y., Zhong, N., Chen, L

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