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When activated, these receptors trigger intracellular signaling cascades involving cAMP elevation, protein kinase A activation, and hormone-sensitive lipase stimulation, ultimately leading to triglyceride breakdown and fat mobilization

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Systemic reactions may include gastrointestinal disturbances (nausea, diarrhea, abdominal cramps) when large doses are administered intravenously

But there are problems with so-called specificity, meaning there are other reasons values can be abnormal, like diminished kidney function in the case of MMA, and folate deficiency in the case of homocysteine

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