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Lessons Learned from Approval of Aducanumab for Alzheimers Disease

Synthesized primarily in the liver, glutathione travels to every cell in the body, where it neutralizes free radicals, supports detoxification, maintains redox balance, protects mitochondria, regulates immune function, and safeguards DNA

Skin is also more vulnerable to sunburn, eczema and general sensitivity

10.1161/STROKEAHA.108.535765 Stroke 134 PengY.ChangX.LangM

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Discussion Here, we report the serendipitous identification of SP3N, a degrader of the prolyl isomerase FKBP12, which features a minimal design where the known FKBP12 ligand SLF is equipped with an alkylamine extension that conveys the observed degradation properties