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4 Discussion 4.1 Summary of evidence This systematic review and meta-analysis indicate that the active components of Schisandra chinensis exhibit significant protective effects against liver injury in animal models

Pyroptosis activation is highly dependent on direct stimulation of immune cells by pathogen-associated molecular patterns, and its core pathological effect is the massive release of potent pro-inflammatory cytokines such as IL-1 and IL-18

X-CL: Data curation, Writing original draft, Conceptualization

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Logistic regression was used to identify singular CpG sites containing hypermethylation (positive meth.diff values) or hypomethylation (negative meth.diff values)

Mechanical stressors dramatically alter the gene expression, morphology and function of retinal astrocytes and push the cells into a reactive state called astrogliosis that manifests as the inflammation and fibrosis of the lamina, and correlates with weakened ONH architecture, compromised blood supply and axonal loss (86, 98, 99)