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Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

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For example, while enhanced expression of Nrf2 can reduce ROS levels and decrease stress responses (Suzuki et al., 2013), the activation of Nrf2 minimizes cancer cell sensitivity to conventional cancer treatments (e.g., chemotherapy and radiation) (DeNicola et al., 2011)

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It is characterized by hyperproliferation and abnormal differentiation of keratinocytes

Then, GST solution was added (the cell suspension without glutathione was used as the control)