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A vitamin A derivative and form of retinoid, isotretinoin has been shown to have serious side effects for 1 out of every 500 patients taking the medication and can cause serious birth defects in 35% of infants exposed to isotretinoin during pregnancy

10.1016/j.chroma.2007.12.055 115 LuoM.SuiY.TianR.LuN

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Anyone experiencing symptoms of deficiency particularly neurological symptoms should seek medical review promptly rather than relying solely on self-supplementation

treated thyroid cancer cells of different cell lines with selenomethionine (SeMet) (99) and found that SeMet could timedependently upregulate the expression of GADD family genes and arrest cells in cell cycle S phase or G2/M phase to inhibit the proliferation of thyroid cancer cells

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