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doi: 10.1056/NEJM198511143132004 63

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Initially, dexamethasone (DEX) and ursodeoxycholic acid (UDCA) were co-encapsulated via the solid-in-oil-in-water emulsion solvent extraction-evaporation technique, which employs dichloromethane as the only organic solvent and ethanol as a co-solvent in an 80:20 ratio