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Description

aeruginosa , the MexR repressor senses oxidative stress (two Cys residues form disulfides), dissociates from the mexAB-oprM promoter, and derepresses efflux under peroxide stress

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Compared to many free radicals, superoxide has a relatively long half-life that permits diffusion within the cell and therefore, the number of the cellular targets is increased

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Collectively, NNT is therefore a key enzyme bridging cell metabolism and reductive stress

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Baker, H., Sidorowicz, A., Sehgal, S

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