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STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells

10.1111/j.1349-7006.2000.tb00880.x 12

The cartilage loss, bony change, altered joint mechanics, and chronic inflammatory environment are not the same as a tendon strain or ligament irritation

Key observation: All dose groups began at 0.5mg with gradual escalation over several weeks before reaching maintenance doses

However, the physicochemical stability of these peptides, for instance in normal saline, is not satisfactory

10.1016/j.bcp.2007.11.002 57 LotitoS