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National Institute of Diabetes and Digestive and Kidney Diseases

Resistance training, not just cardio

MOTS-c Primary focus: Mitochondrial metabolism Insulin sensitivity Metabolic aging in women MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is encoded in mitochondrial DNA not the nuclear genome and functions as a mitochondrial-derived peptide that communicates metabolic stress signals systemically

In the United States, the prevalence of obesity among adults was 40.3 percent between 2021 and 2023 (213)Emmerich SD, et al

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Unlike its parent protein, fragment 176-191 has been found to avoid certain effects, such as increasing insulin-like growth factor-1 (IGF-1) levels, affecting carbohydrate metabolism, reducing insulin sensitivity, and promoting long bone growth