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These iron enzymes are located in essentially every subcellular compartment

Conjugation reactions usually involve metabolite activation by a highenergy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product (Hodgson, 2004)

Little research has been done on GST conjugation of neonicotinoids, so this is a promising sign

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doi: 10.3389/fphar.2012.00060 50 GaoKWangCRJiangFWongAYSuNJiangJHet al

Pasquale, Genetics of glaucoma