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Research indicates that FOXO4-DRI can selectively remove senescent cells in chondrocytes, which are the cells found in cartilage

DNA methylation and microRNA-374a-5p (miR-374a-5p) epigenetically regulate macrophage function [190, 191]

306,307,308 Specifically, p53 inhibits glucose uptake and glycolysis, promoting a metabolic shift towards the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, thereby increasing sensitivity to cuproptosis