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The two arms were reasonably well balanced with respect to the presence of cardiovascular comorbidities (angina, valvular disease, congestive heart failure, hypertension, diabetes, hyperlipidemia, and cardiac revascularization), with the placebo arm having marginally higher rates of cardiac arrhythmia (19% vs 11%), myocardial infarction (MI) (39% vs 30%), and obesity (BMI 30 kg/m 2 78% vs 66%)

Based on the fact that the redox reactive GSHmenadione adducts are excreted, a protective mechanism was proposed to be implicated in catabolic tissues, such as the liver [144,145]

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