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doi: 10.1016/j.jhep.2019.06.021 4 de VriesMWesterinkJKaasjagerKde ValkHW

(iii) The linear exchange function slope

Reumann MK, Schaefer J, Titz B, Aspera-Werz RH, Wong ET, Szostak J, et al

10.1016/j.freeradbiomed.2018.09.043 66 HouW.XieY.SongX.SunX.LotzeM

Pharmacokinetic data from the trial suggested that administering carboplatin before olaparib may be the preferred treatment schedule to enhance the overall clinical benefit of this combination therapy, as pre-exposure to carboplatin causes intracellular accumulation of olaparib ( P = 0.013), thereby improving its effective availability within tumour cells