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Therefore, our study explored the impact of metformin on the proliferation, differentiation, and ferroptosis of endogenous NSCs during SCI repair through in vitro and in vivo experiments, further highlighting the role and molecular mechanisms of metformin in neuroregeneration and neuroprotection

Suzuki M, Shiraha H, Fujikawa T, Takaoka N, Ueda N, Nakanishi Y, et al

Upregulation of Nrf2 activity has been shown to promote mitochondrial biogenesis via peroxisome proliferatoractivated receptor gamma coactivator-1 alpha (PGC-1) and to improve the expression of genes involved in mitochondrial quality control, such as mitofusin-2 (MFN2) and optic atrophy 1 (OPA1)

doi:10.3389/fnagi.2021.647285

Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence

This process cant happen when your immune system blocks your intrinsic factor