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FIGURE 1 While AMPK activation explains many of metformins systemic effects, its glucose-lowering action appears to rely more directly on redox modulation of hepatic gluconeogenesis

In a follow-up human study, a pharmacometabolomic approach has been used to identify individuals susceptible to acetaminophen-induced liver injury [87]

doi: 10.1001/archpedi.161.4.326 98 KonstantareasM

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HSC activation is associated with metabolic reprogramming toward mitochondrial oxidative phosphorylation 41 , whereas activation of differentiated myeloid cell is associated with increased glycolysis 43

For long-term management of chronic hearing loss or tinnitus, nondrug therapies are often used