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Neuroscience letters 788:136827

doi: 10.1002/jcp.27678 94 KomatsuNTakayanagiH

Compared to other AMD treatment options, which may relieve symptoms but fail to stall progression, pegcetacoplan was found to not only slow down the progression of AMD to GA but to increase its efficacy at doing so over time

Reactive electrophilic species (RES) have electron-deficient centers and can react with the nucleophilic Cys thiol group via the thiol- S -alkylation chemistry (Figure 2) (Antelmann and Helmann, 2011)