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Phosphorylation and activation of cytosolic phospholipase A2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets

doi: 10.1038/sj.emboj.7601116 6 Al-RomaiyanA.BarakatA.JoseL.MasochaW

Common Symptoms of a Sulfa Allergy Can Include: Skin rashes or hives (most common) Fever Swelling of the face, mouth, or tongue Stomach cramps In severe cases, anaphylaxis Drugs commonly linked to Sulfa Allergy: Antibiotics Sulfamethoxazole (Co-trimoxazole, Bactrim, Septra) Sulfadiazine Sulfisoxazole Anti-inflammatory / Autoimmune Sulfasalazine Dapsone Diuretics Thiazides (Hydrochlorothiazide, Chlorthalidone, Indapamide) Loop diuretics (Furosemide, Bumetanide, Torsemide) Carbonic anhydrase inhibitors (Acetazolamide, Dorzolamide, Brinzolamide) Antidiabetic agents Sulfonylureas (Glibenclamide, Glipizide, Glimepiride, Gliclazide) Others Celecoxib (COX-2 inhibitor NSAID) Probenecid Key takeaway: Not every patient with a sulfa allergy will react to all sulfonamide drugs but vigilance saves lives

And while qualitative assessment of brain GSH studies is relatively consistent, there may be other factors contributing to heterogeneity

methamphetamine also has a ~ 2 fold higher affinity (lower IC 50 ) for inhibiting SERT compared to amphetamine (Rickli et al, 2015) Indications: Attention-deficit disorders in children over 6 years of age Short term treatment for obesity (Exogenous Obesity) - however its use is controversial and often not recommended

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