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Okada T, Fujimoto K, Fushimi Y, Akasaka T, Thuy DHD, Shima A, et al

Figure 6 They can be divided into two subclasses on the basis of their structure and mode of action: the elongated amphiphilic cationic lantibiotics (Nisin, Lactococcin, and Pediocin) are active through the formation of pores, leading to the dissipation of membrane potential and the efflux of small metabolites from target cells

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These findings suggest that epigenetic inactivation and regulation of the GPx3 pathway may be critical in the development and progression of different types of cancers

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A key element for the chloride shift is the upregulation of the chloride-extruding transporter molecule (KCC2) (Rivera et al., 1999)