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To view a copy of this license, visit About this article Cite this article Pagan, C., Benabou, M., Leblond, C

doi:10.1016/j.neulet.2023.137304

Consequently, aloe-emodin may ameliorate DKD progression via a dual mechanism: by inhibiting lactate production whilst simultaneously blocking lactylated modifications of key proteins (particularly through regulating H3K18la levels), thereby disrupting the self-perpetuating cycle of metabolic disorder-lactylation-epigenetic activation within renal tissue

The mediating effects were 0.005 (IgD + CD24 + B cell %B cell), 0.003 (activated & resting CD4 regulatory T cell absolute count), 0.003 (CD3 on terminally differentiated CD8 + T cell), and 0.006 (HLA DR on myeloid dendritic cell), respectively

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