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However, as the altered microglial expression of the H 1 and H 4 receptors depends on the activation state of mast cells (Dong et al., 2017) this may be suggestive that mast cell sources of histamine, not just neuronal sources, are crucial in the initiation of neuroinflammation

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This environmental stress can damage skin cells, prompting an inflammatory response that leads to melanin production as part of the skins defense