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Description

The following figure illustrates how the state of iron metabolism influences distinct cellular fates ( Figure 3 )

Wang HH, Liu M, Li X, Portincasa P, Wang DQ

NETosis is induced dependent on ROS, which majorly originates from nicotinamide adenine dinucleotide phosphate oxidases, whose activation is dependent on an elevation in cytoplasmic Ca 2+ concentration and occasionally on ROS generation in the mitochondria (144)