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Additionally, inhaled delivery avoids first pass metabolism, provides direct treatment, and potentially limits systemic off-target effects making it ideal for pulmonary protection [97]

Specifically, chronic inflammation and oxidative stress damage the vasa nervorum the microscopic capillary networks that supply oxygen and nutrients to the peripheral nerves

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Jun-Ichi T, Hajime N, Katsuaki T, Masahiko I, Atsushi N, Norio U et al

conducted a study on humanized mice carrying pathogenic p.H454Y mutations