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In addition to cytoskeletal dynamics influencing FBP production via aldolase regulation, another trigger for increased glycolysis might be an elevated glucose uptake during cell migration 60

Lymphatic targeting may be achieved via the delivery of macromolecular therapeutics (for example, proteins and peptides), small-molecule therapeutics in association with macromolecular carriers (for example, nanoparticles, polymers, liposomes and dendrimers) or small-molecule therapeutics that associate, in situ , with endogenous macromolecular constructs (for example, lipoproteins and proteins) or cells that are transported from interstitial tissues via lymphatic rather than blood capillaries

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Unlike Phase 1, which relies primarily on enzyme activity, Phase 2 conjugation requires an adequate and ongoing supply of specific substrates to safely neutralize activated metabolites