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S.IliopoulosD.KaratzasT.et al

Sermorelin has a half-life of around 11 to 12 minutes, meaning half of the peptide is processed by the pituitary gland within this time (5)

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Although earlier studies suggest no agerelated decline in GH responsiveness to GHRH, more recent reports indicate a gender-independent, age-related decline in acute GH responsiveness to GHRH and ghrelin (16)

A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]

[1] [2] Some patients may benefit from extending the time between dose increases if gastrointestinal symptoms are problematic