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(73) employed transcription activator-like effector nuclease (TALEN) technology to develop Uox knockout mouse models in a pure C57BL/6J background (73)

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The disruption of the CV system encompasses ED and subsequent down-stream effects, and increased risks of deep vein thrombosis, pulmonary embolism, and bleeding events ( 1 receptor and angiotensin 1-7 MAS receptor (67) and leads to arrhythmic sequelae in acute and post-acute COVID-19 (72)

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422 To date, four distinct classes of mammalian MAPKs have been identified: extracellular signal-regulated kinases (ERK1 and 2), c-jun N-terminal kinases (JNK1-3), p38 MAPK, and ERK5