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Gut microbiota metabolites, such as SCFAs and isoalloLCA, enhance Treg function by upregulating Foxp3 [367, 368]

Gene editing could be used to modify MSCTs to express cytokine inhibitors or suppress inflammatory pathways, thereby reducing the severity of CS

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doi: 10.1016/0005-2744(73)90192-7 63 van LeyenK.DuvoisinR

Safety is favorable but irrelevant to efficacy