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High-use accounts would continue to be monitored, with fines of up to $50 per 1,000 gallons of Tier 2 usage possible for accounts that stay high for two months or more, and potential service disconnection for continued non-compliance

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A highly promising recently developed protocol including marrow reduction and pretransplant immunosuppression, followed by low-intensity conditioning with ATG, has been shown to result in a low risk of toxicity and durable engraftment in class 3 HR patients receiving cells from unrelated and related donors

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This is crucial for maintaining the sterility and safety of the solution over its refrigerated lifespan