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The presence of MGMT is an important reason for the resistance of GBMs to TMZ ( ROS are reactive substances produced by oxygen reduction, including hydrogen peroxide (H 2 O 2 ), organic hydroperoxide (ROOH), singlet oxygen ( 1 O 2 ), ozone (O 3 ), superoxide anion (O 2 ), hydroxyl radical (OH), and peroxyl radical (ROO) ( In gliomas, appropriate amounts of ROS can activate growth-related signalling pathways, induce DNA mutations, and promote invasion and metastasis ( 2 ROS production and antioxidant defence systems ROS production is caused by exogenous environmental stimuli or endogenous metabolism

doi: 10.1186/s12935-022-02624-9 74

Short chains of fewer than 50 amino acids penetrate cell membranes and tissue barriers more readily than larger protein complexes, enabling target specific receptor engagement with greater efficiency

Nature 578 , 593599 (2020)

Nootkatone attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats