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Discussion The COVID-19 pandemic continues to pose myriad challenges to global public health

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The tumor microenvironment is highly spatially heterogeneous, with gradients in oxygen, nutrients, pH, and growth factor concentrations [206]

In the 2024 WADA Prohibited List (World Anti-Doping Agency, 2024c) Section 4: hormone and metabolic modulators, AIs (Subsection S4.1) and anti-estrogenic substances, including anti-estrogens and SERMs (Subsection S4.2), are prohibited at all times (in- and out-of-competition)

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