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JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification

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In addition to elevated mitochondrial antioxidants previously discussed, such as SOD2, a decrease in the enzyme monoamine oxidase (MAO), which catalyzes amine oxidation reactions and the production of reactive oxygen species (ROS), appears to be another mechanism by which exercise protects the heart from IR (Kavazis et al., 2009

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