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A review of studies indicated that combining the nasal pathway with hybrid nanomedicine techniquessuch as magnetic navigation, low-intensity focused ultrasound, or photobiomodulation pre-treatmentcould serve as a potential route for BBB-crossing drug delivery

This margin of safety provides reassurance, though caution remains appropriate given the limited formal human studies

Mixed reports indicate that EDTA does not cross the blood-brain barrier, but this is in contrast to reports that EDTA may cause increased symptoms of lead poisoning or mercurialism [87]

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