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The link between ammonia-induced cell death and necrosis is likely due to the local accumulation of ammonia at high concentrations, which disrupts cell membrane integrity and initiates necrotic responses such as cell swelling, membrane rupture, and the leakage of intracellular components into the extracellular space (117, 118)

Using a combination of backcrossing and deep sequencing as previously described (Lehrbach et al., 2017), we identified 6 alleles in 4 genes that are required for SKN-1 activation in amdh-1 mutants (supplemental figure 2c)

Retatrutide Retatrutide is a synthetic peptide agonist of multiple hormone receptors including GLP-1, GIP, and glucagon receptors

10.1186/s13028-017-0341-9 115

Understanding potential concerns enables informed decision-making and appropriate monitoring

BMC Med (2016) 14:73