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The other was to reproduce only the tip of the spike protein, known as binding domain receptor (RBD)

KN-L, VM, AO, SF, and JO conducted most of the experiments and wrote the main manuscript

In the mitochondrial matrix, reducing equivalent from the NADH generated from the fuel oxidation process can also be directly transferred to NADP + by the nicotinamide nucleotide transhydrogenase (NNT) to generate NADPH, therefore coupling the production of reducing power for oxidative phosphorylation metabolism (OXPHOS) and antioxidant systems (Figure 1)

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All participants were counseled on lifestyle modification, including a daily 500-kcal calorie deficit and at least 150 minutes of physical activity per week