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doi: 10.1242/jcs.093849

Two Longterm Phase 3 Studies of Enarodustat ( JTZ 951) in Japanese Anemic Patients with Chronic Kidney Disease Not on Dialysis or on Maintenance Hemodialysis: SYMPHONY NDLong and HDLong Studies

Peak fractions from anion-exchange chromatography (IEX) were concentrated using centrifugal concentrators (Amicon, 30 kDa molecular weight cut-off (MWCO)) and polished by size exclusion chromatography (SEC, HiLoad 16/600 Supderdex 200 pg, Cytiva) in CRBN SEC buffer (50 mM HEPES/NaOH pH 7.4, 150 mM NaCl, 1 mM TCEP)