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Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, et al

Moreover, ox-LDL triggers the immune response, damaged endothelial cells are activated and express monocyte chemoattractant proteins (MCP)-1 and 8, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, P-selectin and other inflammatory factors (68)

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By blocking the vascular endothelial growth factor, bevacizumab damages the tumor vascular system that leads to the breakdown of metastatic tumor cells in the dermis