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4 Novo Nordisk / NEJM CagriSema (cagrilintide + semaglutide)Trial data on the investigational dual GLP-1 + amylin combination CagriSema

Zepbound (November 2023) for chronic weight management Real-world data : Growing post-market evidence supporting efficacy and safety in diverse populations Cardiovascular outcomes : SURPASS-CVOT trial evaluating cardiovascular endpoints Key Differences Summary# Receptor pharmacology : Retatrutide is a triple agonist (GIP/GLP-1/glucagon)

R.WelkerE.et al

Other key class risks: Pancreatitis discontinue and seek evaluation if severe, persistent abdominal pain develops

These peptides may support: tissue recovery protein synthesis repair signaling pathways overall recovery support They are typically considered as part of a broader treatment approach