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If the ACO reports the APP Plus quality measure set and meets the data completeness requirement at 414.1340 of this subchapter on all eCQMs/MIPS CQMs/Medicare CQMs, and the CAHPS for MIPS survey (except as specified in 414.1380(b)(1)(vii)(B) of this subchapter), and receives a MIPS Quality performance category score under 414.1380(b)(1) of this subchapter, for the applicable performance year

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This selectivity is crucial because many methyltransferases play essential roles in neurotransmitter metabolism, gene expression, and protein function