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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis

PMC5826726

For those on plant-based diets, fortified foods like some breakfast cereals, nutritional yeasts, and plant-based milks are important

Monitoring and tracking your progress Objective tracking eliminates guesswork and provides the data needed for informed protocol adjustments

It is the why NNMT is interesting at all paper

However, clinical trials in humans have demonstrated mixed results